Angelo Mosca attended the University of Notre Dame and was drafted by the NFL's Philadelphia Eagles in 1959 in the 30th round (350th overall). He had already decided to play in the CFL, in 1958 for the Hamilton Tiger-Cats. He was traded to the Ottawa Rough Riders for Hardiman Cureton on August 15, 1960, and played for the Rough Riders in 1960 and 1961 before joining the Montreal Alouettes in 1962. He played his remaining years, 1963 to 1972 in Hamilton and was a 5-time All-Star. Angelo played in 9 Grey Cup games, more than any other player in CFL history, tied with his teammate John Barrow. Mosca's teams won 5 Grey Cup games, one with the Ottawa Rough Riders and four with the Hamilton Tiger-Cats.
Mosca has lived in and around Hamilton for many years and currently lives in St. Catharines, Ontario with his wife, Helen. He authored a book with Steve Milton called ‘Tell Me To My Face’, published by Lulu Canada Inc. The book was released in September 2011. Mosca appeared on several Canadian TV commercials in the 1970s and 1980s. Mosca still makes PR appearances for the league and the Ticats and for other businesses. He was elected to the Canadian Football Hall of Fame in 1987.